68Ga-DOTATATE-positron emission tomography imaging in spinal meningioma

Philipp Jorg Slotty; Florian Friedrich Behrendt; Karl-Josef Langen; Jan Frederick Cornelius

doi:10.4103/0974-8237.135224

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CASE REPORT

Year : 2014 | Volume : 5 | Issue : 1 | Page : 44-46

⁶⁸Ga-DOTATATE-positron emission tomography imaging in spinal meningioma

Philipp Jorg Slotty¹, Florian Friedrich Behrendt², Karl-Josef Langen³, Jan Frederick Cornelius⁴
¹ Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada; Department of Neurosurgery, Heinrich-Heine University Dusseldorf, Germany
² Department of Nuclear Medicine, University Hospital RWTH Aachen, Germany
³ Department of Nuclear Medicine, University Hospital RWTH Aachen; Department of Neuroscience and Medicine (INM-4), Julich Research Centre, Julich, Germany
⁴ Department of Neurosurgery, Heinrich-Heine University Dusseldorf, Germany

Correspondence Address:
Philipp Jorg Slotty
Department of Stereotactic and Functional Neurosurgery, Gordon and Leslie Diamond Health Care Centre, Vancouver General Hospital, 8105-2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0974-8237.135224

Imaging with positron emission tomography (PET) and ⁶⁸ Ga-DOTA peptides is a promising method in intracranial meningiomas. Especially in recurrent meningioma discrimination between scar tissue and recurrent tumor tissue in magnetic resonance imaging (MRI) is often difficult. We report the first case of ⁶⁸ Ga-DOTATATE-PET/computed tomography (PET/CT) imaging in recurrent spinal meningioma. A 64-year-old Caucasian female patient was referred to our department with the second recurrence of thoracic meningothelial meningioma. In MRI, it remained unclear if the multiple enhancements seen represented scar tissue or vital tumor. We offered ⁶⁸ Ga-DOTATATE-PET/CT imaging in order to evaluate the best strategy. ⁶⁸ Ga-DOTATATE-PET/CT imaging revealed strong tracer uptake in parts of the lesions. The pattern did distinctly differ from MRI enhancement. Multiple biopsies were performed in the PET-positive and PET-negative regions. Histological results confirmed the prediction of ⁶⁸ Ga-DOTATATE-PET with vital tumor in PET-positive regions and scar tissue in PET-negative regions. Differentiating scar tissue from tumor can be challenging in recurrent spinal meningioma with MRI alone. In the presented case, ⁶⁸ Ga-DOTATATE-PET imaging was able to differentiate noninvasively between tumor and scar.

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