The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report

Cengiz Ozturk; Ayhan Kanat; Mehmet Dumlu Aydin; Coskun Yolas; Mehmet Esref Kabalar; Betul Gundogdu; Aslihan Duman; Ilyas Ferit Kanat; Cemal Gundogdu

doi:10.4103/0974-8237.156056

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ORIGINAL ARTICLE

Year : 2015 | Volume : 6 | Issue : 2 | Page : 69-75

The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report

Cengiz Ozturk¹, Ayhan Kanat², Mehmet Dumlu Aydin³, Coskun Yolas⁴, Mehmet Esref Kabalar⁵, Betul Gundogdu⁶, Aslihan Duman⁷, Ilyas Ferit Kanat⁸, Cemal Gundogdu⁶
¹ Erzurum Regional Research and Education Hospital Family Physician, Erzurum, Turkey
² Department of Neurosurgery, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
³ Department of Neurosurgery, Medical Faculty, Ataturk University, Erzurum, Turkey
⁴ Department of Neurosurgery, Erzurum Regional Research and Education Hospital Family Physician, Erzurum, Turkey
⁵ Department of Pathology, Erzurum Regional Research and Education Hospital Family Physician, Erzurum, Turkey
⁶ Department of Pathology, Medical Faculty, Ataturk University, Erzurum, Turkey
⁷ Department of Pathology, Giresun University, Medical Faculty, Giresun, Turkey
⁸ Department of Internal Medicine, Atatürk Training and Research Hospital, Ankara, Turkey

Correspondence Address:
Dr. Ayhan Kanat
Department of Neurosurgery, Medical Faculty, Recep Tayyip Erdogan University, Merkez - 53100 Rize
Turkey

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0974-8237.156056

Context: Somato-sensitive innervation of bowels are maintained by lower segments of spinal cord and the blood supply of the lower spinal cord is heavily dependent on Adamkiewicz artery. Although bowel problems are sometimes seen in subarachnoid hemorrhage neither Adamkiewicz artery spasm nor spinal cord ischemia has not been elucidated as a cause of bowel dilatation so far. Aims: The goal of this study was to study the effects Adamkiewicz artery (AKA) vasospasm in lumbar subarachnoid hemorrhage (SAH) on bowel dilatation severity. Settings and Design: An experimental rabbit study. Materials and Methods: The study was conducted on 25 rabbits, which were randomly divided into three groups: Spinal SAH (N = 13), serum saline (SS) (SS; N = 7) and control (N = 5) groups. Experimental spinal SAH was performed. After 21 days, volume values of descending parts of large bowels and degenerated neuron density of L5DRG were analyzed. Statistical Analysis Used: Statistical analysis was performed using the PASW Statistics 18.0 for Windows (SPSS Inc., Chicago, Illinois). Two-tailed t-test and Mann-Whitney U-tests were used. The statistical significance was set at P < 0.05. Results: The mean volume of imaginary descending colons was estimated as 93 ± 12 cm ³ in the control group and 121 ± 26 cm ³ in the SS group and 176 ± 49 cm ³ in SAH group. Volume augmentations of the descending colons and degenerated neuron density L5DRG were significantly different between the SAH and other two groups (P < 0.05). Conclusion: An inverse relationship between the living neuronal density of the L5DRG and the volume of imaginary descending colon values was occurred. Our findings will aid in the planning of future experimental studies and determining the clinical relevance on such studies.

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