Home | About JCVJS | Editorial board | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Journal of Craniovertebral Junction and Spine
Search Articles   
Advanced search   

   Table of Contents  
Year : 2021  |  Volume : 12  |  Issue : 3  |  Page : 263-268  

Risk-benefit assessment of major versus minor osteotomies for flexible and rigid cervical deformity correction

1 Departments of Orthopaedic and Neurosurgery, Division of Spinal Surgery, NYU Langone Medical Center, NY Spine Institute, New York, NY, USA
2 Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA
3 Department of Neurosurgery, University of Virginia Medical Center, Charlottesville, VA, USA
4 Department of Spine Surgery, Denver International Spine Center, Presbyterian St. Luke's, Rocky Mountain Hospital for Children, Denver, CO, USA
5 Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, USA
6 Department of Orthopedic Surgery, SUNY Downstate, New York, NY, USA
7 Department of Orthopaedic Surgery, NYU Langone Medical Center, New York, NY, USA
8 Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
9 Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA
10 Department of Orthopaedic Surgery, Swedish Neuroscience Institute, Seattle, WA, USA
11 Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA

Date of Submission09-Mar-2021
Date of Acceptance30-Apr-2021
Date of Web Publication8-Sep-2021

Correspondence Address:
Peter Gust Passias
Departments of Orthopaedic and Neurosurgery, New York Spine Institute, NYU Langone Orthopedic Hospital, 301 East 17th St., New York, NY 10003
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcvjs.jcvjs_35_21

Rights and Permissions

Introduction: Osteotomies are commonly performed to correct sagittal malalignment in cervical deformity (CD). However, the risks and benefits of performing a major osteotomy for cervical deformity correction have been understudied. The objective of this retrospective cohort study was to investigate the risks and benefits of performing a major osteotomy for CD correction.
Methods: Patients stratified based on major osteotomy (MAJ) or minor (MIN). Independent t-tests and Chi-squared tests were used to assess differences between MAJ and MIN. A sub-analysis compared patients with flexible versus rigid CL.
Results: 137 CD patients were included (62 years, 65% F). 19.0% CD patients underwent a MAJ osteotomy. After propensity score matching for cSVA, 52 patients were included. About 19.0% CD patients underwent a MAJ osteotomy. MAJ patients had more minor complications (P = 0.045), despite similar surgical outcomes as MIN. At 3M, MAJ and MIN patients had similar NDI, mJOA, and EQ5D scores, however by 1 year, MAJ patients reached MCID for NDI less than MIN patients (P = 0.003). MAJ patients with rigid deformities had higher rates of complications (79% vs. 29%, P = 0.056) and were less likely to show improvement in NDI at 1 year (0.95 vs. 0.54, P = 0.027). Both groups had similar sagittal realignment at 1 year (all P > 0.05).
Conclusions: Cervical deformity patients who underwent a major osteotomy had similar clinical outcomes at 3-months but worse outcomes at 1-year as compared to minor osteotomies, likely due to differences in baseline deformity. Patients with rigid deformities who underwent a major osteotomy had higher complication rates and worse clinical improvement despite similar realignment at 1 year.

Keywords: Fixed deformity, flexible deformity, osteotomy, pedicle subtraction osteotomy, rigid deformity, vertebral column resection

How to cite this article:
Passias PG, Passfall L, Horn SR, Pierce KE, Lafage V, Lafage R, Smith JS, Line BG, Mundis GM, Eastlack R, Diebo BG, Protopsaltis TS, Kim HJ, Scheer J, Burton DC, Hart RA, Schwab FJ, Bess S, Ames CP, Shaffrey CI, On Behalf of the International Spine Study Group. Risk-benefit assessment of major versus minor osteotomies for flexible and rigid cervical deformity correction. J Craniovert Jun Spine 2021;12:263-8

How to cite this URL:
Passias PG, Passfall L, Horn SR, Pierce KE, Lafage V, Lafage R, Smith JS, Line BG, Mundis GM, Eastlack R, Diebo BG, Protopsaltis TS, Kim HJ, Scheer J, Burton DC, Hart RA, Schwab FJ, Bess S, Ames CP, Shaffrey CI, On Behalf of the International Spine Study Group. Risk-benefit assessment of major versus minor osteotomies for flexible and rigid cervical deformity correction. J Craniovert Jun Spine [serial online] 2021 [cited 2023 Jun 4];12:263-8. Available from: https://www.jcvjs.com/text.asp?2021/12/3/263/325693

   Introduction Top

Sagittal alignment and balance are intricately linked, and together have a profound impact on health-related quality of life (HRQL). The range of normal values of sagittal alignment including cervical lordosis, thoracic kyphosis, lumbar lordosis, and pelvic incidence have been linked to one another via a “chain of correlation” to create the optimal alignment and balance which is unique for each individual patient.[1] Glassman et al. demonstrated that at increasing degrees of positive sagittal balance patients have improvement in HRQL outcomes.[2]

Specific to the cervical spine, sagittal imbalance due to cervical spine deformity (CD) leads to an increase in effort and energy expenditure to maintain an upright posture. CD can severely limit patients' quality of life as it can restrict horizontal gaze, limit eating and ambulation, and cause Pain and neurologic dysfunction.[3],[4] Trauma, metabolic bone disease, ankylosing spondylitis, iatrogenic malalignment, and age-related degeneration are all potential causes of cervical sagittal imbalance. Sagittal imbalance can be either focal with maintained global alignment or globally imbalanced with a C7 plumb line >2 cm. Several attempts have been made to classify CD types and stratify surgical intervention along these lines. Importantly, these can lead to either flexible or rigid deformities.

Surgical techniques that have been developed over time have specific indications for the management of CD. Techniques to address CD range from minor procedures such as multilevel anterior cervical discectomy and fusion and/or corpectomy and facet osteotomies to major surgical interventions including osteotomies such as pedicle subtraction osteotomy (PSO) and vertebral column resection (VCR). Approaches for deformity corrective surgery are also quite variable: including anterior only, posterior only, anterior-posterior, posterior-anterior, anterior-posterior-anterior, and posterior-anterior-posterior options.[5],[6] Determining the optimal procedure for a particular deformity can be challenging as the ideal is to restore balance without overcorrection, and minimizing surgical morbidity.

Achieving deformity correction to normal values may appear ideal on the surface however extensive surgical intervention comes at a cost. Major three-column resection osteotomies have a complication rate of over 50%, and there is a poor understanding of the long-term benefits and risks of these major osteotomies compared to minor osteotomies. While major osteotomies offer a larger degree of deformity correction, at a certain degree the maximum quality of life attained begins to plateau and regress due to increased complications and risk of overcorrection. The goal of this study was to assess the risks and benefits of major versus minor osteotomies for flexible and rigid cervical deformity correction.

   Methods Top

Data source

This study is a retrospective review of a prospectively collected database of CD patients enrolled from 13 sites within the United States. Internal Review Board approval was obtained at each participating site before study initiation and informed consent was given by each included patient. Inclusion criteria for the database were patients ages ≥18 years, and radiographic evidence of CD at baseline assessment, defined as the presence of at least 1 of the following: cervical kyphosis (C2–7 Cobb angle >10°), cervical scoliosis (C2–7 coronal Cobb angle >10°), C2–7 sagittal vertical axis (cSVA) >4 cm, or chin-brow vertical angle (CBVA) >25°. CD patients meeting radiographic inclusion with available baseline and 1-year follow-up data were included in this study. Patients with active tumors or infections were excluded from the study.

Data collection

Demographic and clinical data collected included patient age, sex, body mass index (BMI), prior cervical surgery, and Charlson Comorbidity Index. Surgical data collected included operative time, estimated blood loss, surgical approach, off-label use of bone morphogenetic protein 2, osteotomy use and the number of osteotomies, levels fused, and instrumentation used.

Patients were evaluated using full-length free-standing lateral spine radiographs (36” long-cassette) at baseline and 1-year postoperative follow-up visit. Radiographs were analyzed using dedicated and validated software (SpineView®; ENSAM, Laboratory of Biomechanics, Paris, France) at a single center with standard techniques.[7],[8],[9] Measured cervical spine parameters included cSVA (offset from the C2 plumbline and the postero-superior corner of C7), C2–C7 lordosis (CL: Cobb angle between C2 inferior endplate and C7 inferior endplate), T1 slope minus CL (TS–CL: Mismatch between T1 slope and cervical lordosis), and CBVA (angle subtended between the vertical line and the line from the brow to the chin). Measured spinopelvic parameters included: sagittal vertical axis (SVA: C7 plumb line relative to the posterior-superior corner of S1), pelvic incidence minus lumbar lordosis (PI-LL: Mismatch between pelvic incidence and lumbar lordosis), and pelvic tilt (PT: Angle between the vertical and the line through the sacral midpoint to the center of the two femoral heads).

Patient stratification

Patients were categorized based on undergoing a major osteotomy (MAJ) defined as either a PSO or VCR or a minor osteotomy (MIN). The flexibility of the deformity was assessed using C2–C7 lordosis and T1S change >10° between flexion and extension. A sub-analysis was performed on patients with fixed/rigid (<10° difference between flexion and extension) and nonfixed/flexible (>10° change between flexion and extension) alignment for cervical lordosis for both major and minor deformities.

Statistical analysis

Propensity score matching (PSM) was performed controlling for baseline cSVA to generate two groups with similar baseline deformity, with one group who had a major osteotomy and one group with only minor osteotomy. Independent t-tests for continuous variables and Chi-squared tests for categorical variables were used to assess differences between MAJ and MIN. Two-sided P < 0.05 were considered statistically significant. All analyses were performed using All analyses were performed using SPSS software (IBM Corp. IBM SPSS Statistics for Windows, v23.0. Armonk, NY, USA).

   Results Top

Patient demographics

137 CD patients were included (61.6 years old, 65.2% female, BMI 29.2 kg/m2). The most common diagnoses for these CD patients were degenerative kyphosis (48.2%), stenosis or myelopathy (20.0%), and iatrogenic kyphosis (14.1%). 30.3% of patients had depression, 29.2% had a history of smoking, and 14.6% had osteoporosis. About 38.6% of patients had prior cervical spine surgery. There were 26 patients (19.0%) who underwent a major (MAJ) osteotomy (20 PSO, 6 VCR). Major osteotomy locations ranged from C4-T4 with the most common occurrences T1 and T2 (8 patients, and 4 patients).

After PSM, there were 26 MAJ and 26 min patients. MAJ and MIN had no differences in any baseline radiographic parameters, with the exception of cSVA (MAJ: 62.5 mm, MIN: 42.0 mm, P = 0.002). There were no significant differences in age gender, or BMI between patients who underwent a MAJ or MIN osteotomy during their primary surgery [all P > 0.05, [Table 1]]. Frailty scores did not differ between MAJ and MIN patients, as well as other comorbidities, including smoking status, diabetes, osteoporosis, and depression [all P > 0.05, [Table 1]].
Table 1: Demographic and clinical factors compared between patients undergoing a major or minor osteotomy

Click here to view

Surgical details and complications

MAJ patients trended toward more minor complications compared to MIN patients (50% vs. 23%, P = 0.083), however, there were no differences in levels fused (11.1 vs. 9.8, P = 0.274), blood loss (1200cc vs. 1087cc, P = 0.91), operative time (484.0 vs. 565.2 P = 0.83), or any postoperative complication as compared to MIN patients [73% vs. 62%, P = 0.385, [Table 2]].
Table 2: Surgical factors compared between major and minor osteotomy patients

Click here to view

Pre- and post-operative radiographic alignment compared between MAJ and MIN

There were significant differences in preoperative T1 slope and cervical lordosis between MAJ and MIN patients after the PSM was performed controlling for baseline cSVA [both P < 0.05, [Table 3]]. Postoperatively, MAJ and MIN achieved similar cervical and global sagittal alignment (all P > 0.05).
Table 3: Radiographic alignment compared between major and minor osteotomy patients both pre- and 1 year post-operatively

Click here to view

Health-related quality of life scores

At 3M postoperative, MAJ and MIN patients had similar NDI, mJOA, and EQ5D scores, however by 1 y postoperative MAJ patients reached MCID for NDI less than MIN patients [7.7% vs. 42.3%, P = 0.003, [Table 4]].
Table 4: Health-related quality of life scores compared between major and minor osteotomy patients both pre- and post-operatively

Click here to view

Flexible and rigid cervical deformities

There were 9 (38%) MAJ osteotomy patients with flexible deformity assessed by C2–C7 CL and 17 (65.0%) MAJ patients with rigid deformity. For the MIN osteotomy patients, 9 (38%) patients had flexible deformities and 17 (65.0%) had fixed deformities at baseline.

For flexible deformity patients, there were no differences in minor complications, major complications, or reoperation rates between MAJ and MIN osteotomy patients (all P > 0.05). There were no differences in HRQL outcomes as both groups showed similar rates of improvement in NDI, EQ5D, and mJOA (all P > 0.05). In addition, there were no differences in achieving radiographic alignment between the groups at 1 year (all P > 0.05).

In the analysis of rigid deformity patients, MAJ osteotomy patients had higher rates of complications (79% vs. 29%, P = 0.056) and were less likely to show improvement in NDI at 1 year (0.95 vs. 0.54, P = 0.027). However, both groups had similar reoperation (7% vs. 0%, P > 0.05) and sagittal realignment rates at 1 year (all P > 0.05).

   Discussion Top

The cervical deformity is a complex and crippling array of pathology, representing varied structural drivers and causing the decreased quality of life.[10],[11] Cervical osteotomies are capable of providing powerful deformity correction at the cost of high complication rates.[12] While widely used in thoracolumbar deformity, the applications, utility, and complications of osteotomies in CD have only recently been explored.[13],[14]

This study demonstrates that patients with CD who underwent minor osteotomies were able to achieve the same correction, with improved NDI, as those who underwent major osteotomies. Furthermore, those with rigid deformities who underwent MAJ osteotomy had higher rates of complications and were less likely to improve in NDI than those who underwent MIN osteotomy, despite achieving similar sagittal realignment outcomes at 1 year.

In regards to deformity correction, normative values for cervical lordosis are established, however, the relationship between the restoration of alignment, HRQL, and their clinical significance remains unclear.[15],[16] Similar to our study, Sabou et al. found that when used to manage fixed flexion deformities of the cervical spine in patients with ankylosing spondylitis, cervical osteotomies including pedicle subtraction osteotomies resulted in the restoration of horizontal gaze and sagittal balance as well as in improvement in HRQL.[17] While not statistically significant, a trend toward an increase in the mean C2–C7 lordosis and decrease in mean cSVA was observed in this study in both MAJ and MIN groups postoperatively. Furthermore, the mismatch between TS-CL, which has been suggested to better reflect sufficient cervical lordosis, also decreased in both groups indicating improved cervical lordosis. Interestingly, there was no difference in the complication rates between the MAJ and MIN groups overall, in contrast to previous literature citing high complication rates for major cervical osteotomies.[12],[18]

Our study demonstrated similar improvements in mJOA, and EQ5D scores amongst both groups at all points; however, at 1-year after surgery, there was a significant difference in NDI for MAJ patients with fewer reaching MCID than MIN patients. Given the same deformity correction, it may follow that the increased invasiveness of osteotomies lessens the improvement that may be achieved through the same correction obtained without osteotomies, or perhaps fewer levels fused.

Management of rigid versus flexible deformity may require different treatment strategies.[16],[19] Ankylosed, rigid deformities may require larger osteotomies for correction, while flexible deformities may be corrected with the anterior release with or without posterior fusion. This study found no differences in complication or reoperation rates between MAJ or MIN osteotomy patients with flexible deformities. Conversely, MAJ patients with rigid deformities had higher overall complication rates and were less likely to improve in their NDI scores versus MIN osteotomy patients despite similar realignment outcomes at 1 year. These findings suggest that, while some rigid deformities need major osteotomies or they are likely to remain grossly under-corrected, the clinical recovery of these patients is worse. This is likely due to the morbidity of the surgery, but also in part related to greater baseline disability.

A strength of this study is its prospective multicenter design that standardized the collection of detailed clinical and radiographic data. This allowed a broad spectrum of cervical deformities treated by multiple surgeons across multiple institutions to be included. A limitation is that clinical outcomes following CD surgery have not been well explored, and no CD-specific HRQL exists. Passias et al. found no clear relationship between improvements in Ames radiographic modifiers and improvements in HQRLs (mJOA, EQ-5D., and NDI).[20] In addition, when adjusted for cofounders, these HRQLs were not strongly correlated with each other. Therefore any interpretation of HRQLs in this population must be made with caution. Another limitation is that rigid deformities are more likely to require major osteotomies, and there may not be the option to employ a minor osteotomy. The limited number of patients that were included despite the multicenter design can also be considered a limitation. Due to the limited number of patients, several types of osteotomies were combined in the MAJ group. Further work with a larger patient cohort is needed to continue the investigation into which osteotomies are optimal for rigid and flexible deformity correction.

   Conclusions Top

Selecting the appropriate surgery for the appropriate patient is paramount for deformity surgery. Overall, the same correction was achieved with and without osteotomies, with those who did not receive major osteotomies having improved NDI. While the clinical benefit of correction remains to be tightly defined, some rigid deformities require osteotomy to obtain correction. This study suggests patients with rigid cervical deformity may benefit from major osteotomies as part of their correction, they are less likely to show clinical improvement as compared to patients treated with minor osteotomies.

Financial support and sponsorship


Conflicts of interest

The International Spine Study Group (ISSG) is funded through research grants from DePuy Synthes and individual donations, and supported the current work.

   References Top

Boulay C, Tardieu C, Hecquet J, Benaim C, Mouilleseaux B, Marty C, et al. Sagittal alignment of spine and pelvis regulated by pelvic incidence: Standard values and prediction of lordosis. Eur Spine J 2006;15:415-22.  Back to cited text no. 1
Glassman SD, Berven S, Bridwell K, Horton W, Dimar JR. Correlation of radiographic parameters and clinical symptoms in adult scoliosis. Spine (Phila Pa 1976) 2005;30:682-8.  Back to cited text no. 2
Joseph SA Jr., Moreno AP, Brandoff J, Casden AC, Kuflik P, Neuwirth MG. Sagittal plane deformity in the adult patient. J Am Acad Orthop Surg 2009;17:378-88.  Back to cited text no. 3
Gill JB, Levin A, Burd T, Longley M. Corrective osteotomies in spine surgery. J Bone Joint Surg Am 2008;90:2509-20.  Back to cited text no. 4
Ames CP, Smith JS, Scheer JK, Shaffrey CI, Lafage V, Deviren V, et al. A standardized nomenclature for cervical spine soft-tissue release and osteotomy for deformity correction: Clinical article. J Neurosurg Spine 2013;19:269-78.  Back to cited text no. 5
Bridwell KH. Decision making regarding Smith-Petersen vs. pedicle subtraction osteotomy vs. vertebral column resection for spinal deformity. Spine (Phila Pa 1976) 2006;31:S171-8.  Back to cited text no. 6
Deschênes S, Charron G, Beaudoin G, Labelle H, Dubois J, Miron MC, et al. Diagnostic imaging of spinal deformities: Reducing patients radiation dose with a new slot-scanning X-ray imager. Spine (Phila Pa 1976) 2010;35:989-94.  Back to cited text no. 7
Horton WC, Brown CW, Bridwell KH, Glassman SD, Suk SI, Cha CW. Is there an optimal patient stance for obtaining a lateral 36” radiograph? A critical comparison of three techniques. Spine (Phila Pa 1976) 2005;30:427-33.  Back to cited text no. 8
Ilharreborde B, Steffen JS, Nectoux E, Vital JM, Mazda K, Skalli W, et al. Angle measurement reproducibility using EOS three-dimensional reconstructions in adolescent idiopathic scoliosis treated by posterior instrumentation. Spine (Phila Pa 1976) 2011;36:E1306-13.  Back to cited text no. 9
Passias PG, Jalai CM, Lafage V, Lafage R, Protopsaltis T, Ramchandran S, et al. Primary Drivers of Adult Cervical Deformity: Prevalence, Variations in Presentation, and Effect of Surgical Treatment Strategies on Early Postoperative Alignment. Neurosurgery 2018;83:651-9. doi: 10.1093/neuros/nyx438.  Back to cited text no. 10
Passias PG, Bortz C, Horn S, Segreto F, Poorman G, Jalai C, et al. Drivers of cervical deformity have a strong influence on achieving optimal radiographic and clinical outcomes at 1 year after cervical deformity surgery. World Neurosurg 2018;112:e61-8.  Back to cited text no. 11
Smith JS, Shaffrey CI, Lafage R, Lafage V, Schwab FJ, Kim HJ, et al. Three-column osteotomy for correction of cervical and cervicothoracic deformities: Alignment changes and early complications in a multicenter prospective series of 23 patients. Eur Spine J 2017;26:2128-37.  Back to cited text no. 12
Kim HJ, Nemani VM, Daniel Riew K. Cervical osteotomies for neurological deformities. Eur Spine J 2015;24 Suppl 1:S16-22.  Back to cited text no. 13
Nemani VM, Derman PB, Kim HJ. Osteotomies in the cervical spine. Asian Spine J 2016;10:184-95.  Back to cited text no. 14
Scheer JK, Tang JA, Smith JS, Acosta FL Jr, Protopsaltis TS, Blondel B, et al. Cervical spine alignment, sagittal deformity, and clinical implications: A review. J Neurosurg Spine 2013;19:141-59.  Back to cited text no. 15
Diebo BG, Shah NV, Solow M, Challier V, Paulino CB, Passias PG, et al. Adult cervical deformity: Radiographic and osteotomy classifications. Orthopade 2018;47:496-504.  Back to cited text no. 16
Sabou S, Mehdian H, Pasku D, Boriani L, Quraishi NA. Health-related quality of life in patients undergoing cervico-thoracic osteotomies for fixed cervico-thoracic kyphosis in patients with ankylosing spondylitis. Eur Spine J 2018;27:1586-92. doi: 10.1007/s00586-018-5530-3.  Back to cited text no. 17
Theologis AA, Tabaraee E, Funao H, Smith JS, Burch S, Tay B, et al. Three-column osteotomies of the lower cervical and upper thoracic spine: Comparison of early outcomes, radiographic parameters, and peri-operative complications in 48 patients. Eur Spine J 2015;24 Suppl 1:S23-30.  Back to cited text no. 18
Albert TJ. Complications in adult spinal deformity surgery from cervical to lumbar spine: Latest concepts in treating cervical deformity. In: Scoliosis Research Society (SRS) 52nd Annual Meeting and Course Program, Philadelphia, PA; 2017.  Back to cited text no. 19
Passias PG, Horn SR, Oh C, Ramchandran S, Burton DC, Lafage V, et al. Evaluating cervical deformity corrective surgery outcomes at 1-year using current patient-derived and functional measures: Are they adequate? J Spine Surg 2018;4:295-303.  Back to cited text no. 20


  [Table 1], [Table 2], [Table 3], [Table 4]

This article has been cited by
1 Pelvic Nonresponse Following Treatment of Adult Spinal Deformity: Influence of Realignment Strategies on Occurrence
Peter G. Passias, Katherine E. Pierce, Tyler K. Williamson, Oscar Krol, Renaud Lafage, Virginie Lafage, Andrew J. Schoenfeld, Themistocles S. Protopsaltis, Shaleen Vira, Breton Line, Bassel G. Diebo, Christopher P. Ames, Han Jo Kim, Justin S. Smith, Dean Chou, Alan H. Daniels, Jeffrey L. Gum, Christopher I. Shaffrey, Douglas C. Burton, Michael P. Kelly, Eric O. Klineberg, Robert A. Hart, Shay Bess, Frank J. Schwab, Munish C. Gupta
Spine. 2023; 48(9): 645
[Pubmed] | [DOI]
2 A Hierarchical Approach to Realignment Strategies in Adult Cervical Deformity Surgery
Tyler K. Williamson, Jordan Lebovic, Andrew J. Schoenfeld, Bailey Imbo, Rachel Joujon-Roche, Peter Tretiakov, Oscar Krol, Claudia Bennett-Caso, Stephane Owusu-Sarpong, Pooja Dave, Kimberly McFarland, Jamshaid Mir, Ekamjeet Dhillon, Heiko Koller, Bassel G. Diebo, Shaleen Vira, Renaud Lafage, Virginie Lafage, Peter G. Passias
Clinical Spine Surgery: A Spine Publication. 2023; Publish Ah
[Pubmed] | [DOI]
3 The Additional Economic Burden of Frailty in Adult Cervical Deformity Patients Undergoing Surgical Intervention
Peter G. Passias, Nicholas A. Kummer, Tyler K. Williamson, Waleed Ahmad, Jordan Lebovic, Virginie Lafage, Renaud Lafage, Han Jo Kim, Alan H. Daniels, Jeffrey L. Gum, Bassel G. Diebo, Munish C. Gupta, Alexandra Soroceanu, Justin K. Scheer, D. Kojo Hamilton, Eric O. Klineberg, Breton Line, Andrew J. Schoenfeld, Robert A. Hart, Douglas C. Burton, Robert K. Eastlack, Gregory M. Mundis, Praveen Mummaneni, Dean Chou, Paul Park, Frank J. Schwab, Christopher I. Shaffrey, Shay Bess, Christopher P. Ames, Justin S. Smith
Spine. 2022; 47(20): 1418
[Pubmed] | [DOI]


    Similar in PUBMED
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Article Tables

 Article Access Statistics
    PDF Downloaded119    
    Comments [Add]    
    Cited by others 3    

Recommend this journal